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KMID : 1199120090330030169
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Korean Diabetes Journal
2009 Volume.33 No. 3 p.169 ~ p.177
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Diabetes and Osteoporosis
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Oh Ki-Won
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Abstract
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Increased life expectancy and increased obesity have contributed to an increasing incidence of osteoporosis and diabetes mellitus. Recent meta-analyses and cohort studies confirm that diabetes is associated with a higher risk of fracture. Patients with type 2 diabetes exhibit increased fracture risks despite a higher bone mass, which are mainly attributable to non-skeletal risk factors. Patients with type 1 diabetes may have impaired bone formation because of absence of the anabolic effects of insulin and insulin-like growth factor I (IGF-I) system. Several clinical studies have reported adverse skeletal actions of peroxisome proliferator -activated receptor gamma (PPARγ) agonist in humans. Obesity regulates bone metabolism not only by increasing weight loading but also by modulating adipokines that are known to affect bone remodeling.
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KEYWORD
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Adipokines, Diabetes mellitus, Insulin, Insulin-like growth factor-I, Obesity, Osteoporosis, PPAR gamma
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